abstract：:Biopsies obtained from 74 Tunisian women with breast cancer (33 cases), benign breast disease (17 cases), and cervical cancer (24 cases) were assayed for the presence of an antigen cross-reacting with gp52 of the mouse mammary tumor virus (MMTV) in order to determine the frequency and possible prognostic significance ...

journal_title：International journal of cancer

authors： Levine PH,Mesa-Tejada R,Keydar I,Tabbane F,Spiegelman S,Mourali N

更新日期：1984-03-15 00:00:00

abstract：:Cell kinetic studies are of interest for clarifying the concepts of chemotherapeutic strategy in the multimodality therapy of advanced squamous-cell carcinoma of the head and neck. A poorly-differentiated squamous-cell carcinoma of the head and neck heterotransplanted to nude mice was used for analyses of chemotherape...

journal_title：International journal of cancer

authors： Wennerberg J,Alm P,Biörklund A,Killander D,Långström E,Tropé C

更新日期：1984-02-15 00:00:00

abstract：:The most recent data available demonstrate a 120-fold difference between the lowest and highest incidence rates of prostatic cancer, the disease being very common in North America, particularly among Blacks, and in Scandinavia, while it is rare in Japan and other oriental countries. The highest mortality for prostatic...

journal_title：International journal of cancer

authors： Zaridze DG,Boyle P,Smans M

更新日期：1984-02-15 00:00:00

abstract：:The prevalence of adult T-cell-leukemia virus (ATLV) infection was examined in Japanese monkeys living naturally in various parts of Japan and in other species of non-human primates imported into and kept in Japan. Sera of 2,650 Japanese monkeys from 41 troops throughout Japan were tested. High incidences of anti-ATLV...

journal_title：International journal of cancer

authors： Hayami M,Komuro A,Nozawa K,Shotake T,Ishikawa K,Yamamoto K,Ishida T,Honjo S,Hinuma Y

更新日期：1984-02-15 00:00:00

abstract：:AKR-2B mouse fibroblasts were treated with 50 micrograms/ml of crude transforming growth factor (TGF) of human origin. Cell surface proteins of treated cells were radioiodinated and compared to untreated cells at various times after the addition of TGF. Treated cells showed a severalfold increase (approximately 6-fold...

journal_title：International journal of cancer

authors： Marks ME,Brattain MG

更新日期：1984-01-15 00:00:00

abstract：:Specific estrogen, progesterone and androgen receptors were determined in 19 well-characterized squamous-cell carcinoma (SCC) cell lines. Ten of the lines were derived from patients with SCC of the larynx and nine were from patients with SCC originating in other areas of the head and neck. Estrogen receptors (ER) were...

journal_title：International journal of cancer

authors： Virolainen E,Vanharanta R,Carey TE

更新日期：1984-01-15 00:00:00

abstract：:Nude athymic rats of Rowett genetic background were injected subcutaneously with cells from a poorly differentiated human pulmonary adenocarcinoma, following propagation in nude mice. The tumour cells were obtained by thoracentesis and by pleural biopsy during thoracoscopy. So far, we have heterotransplanted 13 differ...

journal_title：International journal of cancer

authors： Korsgaard R,Lindén CJ,Willén R,Willén H,Svensson G,Simonsson BG

更新日期：1983-12-15 00:00:00

abstract：:Exfoliated nasopharyngeal (NP) cells from 62 normal Cantonese Chinese having IgA/VCA antibodies for more than a year and from 39 similar persons without IgA/VCA antibodies, were tested for the presence of EBV/DNA sequences by spot followed by blot hybridization tests, using the cloned internal repeat of B95-8 viral DN...

journal_title：International journal of cancer

authors： Desgranges C,Pi GH,Bornkamm GW,Legrand C,Zeng Y,de-Thé G

更新日期：1983-11-15 00:00:00

abstract：:Primary cultures of rat microvascular endothelial cells were transformed, in vitro, by exposure to Rous sarcoma virus. Transformed cells were followed and evaluated cytogenetically through numerous passages. Highly specific karyotypic changes in karyotype (both structural and numerical) were documented. These changes ...

journal_title：International journal of cancer

authors： Tyrkus M,Diglio CA,Gohle N

更新日期：1983-10-15 00:00:00

abstract：:A highly immunogenic variant of the murine L1210 leukemia cell (L1210/LN-1) for generation of tumor immunity has been obtained from culture of L1210 cells originally fused with human Lesch-Nyhan fibroblasts. In L1210/LN-1 cells, no human chromosomes were identified and chromosomes M1 and No. 1 carried by the parent L1...

journal_title：International journal of cancer

authors： Kawashima K,Nagura E,Watanabe E,Mizoguchi K,Saga S,Isobe K,Nakashima I,Yamada K,Oikawa T,Kojima K

更新日期：1983-10-15 00:00:00

abstract：:The tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) was found to increase the incidence of phenotypic alterations induced by the direct-acting carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in human endometrial stromal cells. Following carcinogen treatment, changes in saturation density, gamma-glutam...

journal_title：International journal of cancer

authors： Siegfried JM,Kaufman DG

更新日期：1983-10-15 00:00:00

abstract：:The effects of three monoclonal antibodies (B3/25, 43/31, and 42/6) reactive with human transferrin (Tf) receptors on growth of normal and malignant myeloid cells were examined using in vitro culture techniques. When added directly to cultures, all three antibodies caused dose-dependent inhibition of normal granulocyt...

journal_title：International journal of cancer

authors： Taetle R,Honeysett JM,Trowbridge I

更新日期：1983-09-15 00:00:00

abstract：:This paper reports the results of 8 years of HLA typing of newly diagnosed nasopharyngeal carcinoma (NPC) patients among Chinese in Singapore, and compares the HLA profile of NPC cases with that of the normal Chinese population. Earlier results had indicated an association with A2 and BW46, but the heterogeneity of th...

journal_title：International journal of cancer

authors： Chan SH,Day NE,Kunaratnam N,Chia KB,Simons MJ

更新日期：1983-08-15 00:00:00

abstract：:Imbalance in the Kb and Db region encoded molecules is observed in Lewis lung carcinoma clones. The uncloned metastatic population and the D122 high-metastatic clone show no expression of H-2Kb products, while the nonmetastatic A9 clone expresses Kb products. Twenty-nine new subclones of 3LL and A9 were analyzed for D...

journal_title：International journal of cancer

authors： Eisenbach L,Segal S,Feldman M

更新日期：1983-07-15 00:00:00

abstract：:Cryopreserved tumour cells obtained from the ascitic fluid of a patient with an ovarian carcinoma were employed to determine the effect on in vitro drug cytotoxicities of varying both drug concentration and exposure time. Four antitumour drugs, in common clinical usage, were selected for study. Tumour-cell survival fo...

journal_title：International journal of cancer

authors： Rupniak HT,Whelan RD,Hill BT

更新日期：1983-07-15 00:00:00

abstract：:Peripheral blood T cells from a patient with T-cell chronic lymphocytic leukemia (T-CLL) failed to respond to mitogenic lectins or alloantigens but could be induced to proliferate by the addition of exogenous interleukin-2 (IL-2). The T-CLL cells also proliferated in response to 12-O-tetradecanoyl phorbol-13-acetate (...

journal_title：International journal of cancer

authors： Vyth-Dreese FA,de Vries JE

更新日期：1983-07-15 00:00:00

abstract：:This paper deals with a spontaneous malignant transformation in one of our XP fibroblast lines. This cell line, designated XP29MA, was derived from a 14-year-old boy who did not show skin tumors or precancerous alterations either at the time of clinical examination or when the biopsy was taken. We have compared the fo...

journal_title：International journal of cancer

authors： Thielmann HW,Fischer E,Dzarlieva RT,Komitowski D,Popanda O,Edler L

更新日期：1983-06-15 00:00:00

abstract：:Epstein-Barr virus genome-positive Burkitt's lymphoma is endemic in Africa and Papua New Guinea and in both countries the tumour is restricted to regions with holoendemic malaria. The present work has compared groups of healthy indigenous individuals living in malarious and non-malarious regions of Papua New Guinea fo...

journal_title：International journal of cancer

authors： Moss DJ,Burrows SR,Castelino DJ,Kane RG,Pope JH,Rickinson AB,Alpers MP,Heywood PF

更新日期：1983-06-15 00:00:00

abstract：:Administration of highly purified interferon to DBA/2 mice inhibited the growth of interferon-sensitive or interferon-resistant Friend erythroleukemia cells implanted subcutaneously. Injection of interferon at the site of tumor inoculation was more effective than injection of interferon intraperitoneally. Histologic e...

journal_title：International journal of cancer

authors： Belardelli F,Gresser I,Maury C,Duvillard P,Prade M,Maunoury MT

更新日期：1983-05-15 00:00:00

abstract：:Leukocyte migration inhibition (LMI) assays were performed using 3 M KCI extracts to detect cell-mediated immune reactions against tumor-associated antigens (TAA) of swine melanoma. Positive LMI reactivity was 70% or greater in melanoma-bearing swine compared to 10% reactivity or less in normal swine tested with extra...

journal_title：International journal of cancer

authors： Hook RR Jr,Hamby CV,Millikan LE,Berkelhammer J,Stills HF Jr,Oxenhandler RW

更新日期：1983-05-15 00:00:00

abstract：:The phorbol esters phorbol 12-retinoate 13-acetate (RPA) and 12-O-tetradecanoyl phorbol 13-acetate (TPA) were used to investigate the role of tumor promoters in the control of hormone response in normal and leukemic myeloid cells. RPA and TPA inhibited the binding of [20-3H]phorbol 12,13-dibutyrate to the leukemic cel...

journal_title：International journal of cancer

authors： Simantov R,Marks F,Fürstenberger G,Sachs L

更新日期：1983-04-15 00:00:00

abstract：:Fibroblast-like cells (F-cells) and epithelial-like (E-cells) derived from cultures of rabbit VX-2 carcinoma released collagenase in both active and latent forms in serum-free medium at a level higher than that of normal rabbit fibroblast cultures. The enhanced capacity of the F-cells to release the enzyme, however, c...

journal_title：International journal of cancer

authors： Dabbous MK,El-Torky M,Haney L,Brinkley SB,Sobhy N

更新日期：1983-03-15 00:00:00

abstract：:From an assessment of the presence of a junctional component in 8,380 pigmented naevi, and histological review of its extent and the presence of inflammation and regression in a sample of 216 junctional and compound naevi, it was determined that naevi excised in summer were more likely to have a junctional component a...

journal_title：International journal of cancer

authors： Holman CD,Heenan PJ,Caruso V,Glancy RJ,Armstrong BK

更新日期：1983-02-15 00:00:00

abstract：:The stability of a cloned murine tumor for sensitivity to NR was examined following growth in vivo in order to test the hypothesis that tumor progression proceeds through the generation and selection of variants. Clonal sensitivity to the [131I]-dUrd elimination assay of NR was assessed for the L5178Y-F9 tumor grown i...

journal_title：International journal of cancer

authors： Chow DA,Ray M,Greenberg AH

更新日期：1983-01-15 00:00:00

abstract：:Transferrin is required for proliferation of most cells in culture. This effect is presumably mediated by the binding of transferrin to its receptor, a surface glycoprotein which is preferentially expressed by actively growing cells. Here we show that normal human fibroblasts cultured in serum, and other media contain...

journal_title：International journal of cancer

authors： Ekblom P,Thesleff I,Lehto VP,Virtanen I

更新日期：1983-01-15 00:00:00

abstract：:The effect of EGF on the soft agar colony-forming ability of fresh human tumor cells was assessed in 40 specimens obtained from various types of carcinoma including those of the breast, endometrium ovary, and other sites. Cells from four established human tumor cell lines (three breast and one endometrial) were also i...

journal_title：International journal of cancer

authors： Pathak MA,Matrisian LM,Magun BE,Salmon SE

更新日期：1982-12-15 00:00:00

abstract：:Seven-day-old mouse embryos were transplanted under the kidney capsule of adult syngeneic recipients which were either X-irradiated, treated with cyclophosphamide, splenectomized or immunized with teratocarcinoma cell lines prior to embryonic transplantation. The yield of malignant tumors was decreased in preirradiate...

journal_title：International journal of cancer

authors： Damjanov I,Bagasra O,Dominis M,Solter D

更新日期：1982-12-15 00:00:00

abstract：:Histologic characteristics of bladder cancer in Boston, USA, Manchester, UK, and Nagoya, Japan, were evaluated. In each of these areas broadly-based series of cases were assembled during a collaborative case-control study. The present analysis was based on 589 cases in Boston, 484 cases in Manchester, and 241 cases in...

journal_title：International journal of cancer

authors： Morrison AS,Proppe KH,Verhoek WG,Aoki K,Leck I,Ohno Y,Obata K

更新日期：1982-12-15 00:00:00

abstract：:The relationship of a basement membrane collagen degrading enzyme (BM collagenase) and plasminogen activator (PA) was studied in a number of non-malignant and malignant human and murine cell lines. Several non-malignant cell lines secreted significant amounts of PA but not detectable BM collagenase activity whereas th...

journal_title：International journal of cancer

authors： Salo T,Liotta LA,Keski-Oja J,Turpeenniemi-Hujanen T,Tryggvason K

更新日期：1982-11-15 00:00:00

abstract：:140.240, an IgG2a mouse monoclonal antibody raised against a cultured human melanoma cell line, was highly specific for melanoma cells as determined by direct and absorption analyses in a mixed hemadsorption assay. Supernatants of doubly cloned hybridomas producing antibody 140.240 reacted with all cultured and fresh ...

journal_title：International journal of cancer

authors： Liao SK,Clarke BJ,Khosravi M,Kwong PC,Brickenden A,Dent PB

更新日期：1982-11-15 00:00:00

abstract：:In this study the antigenic profile of Hodgkin (H) and Sternberg-Reed (SR) cells from cases of Hodgkin's disease was analysed using a large panel of monoclonal and polyclonal antibodies reactive with cells of lymphoid and haemotopoietic origin. The aim of this investigation was, firstly, to throw light on the origin o...

journal_title：International journal of cancer

authors： Stein H,Gerdes J,Schwab U,Lemke H,Mason DY,Ziegler A,Schienle W,Diehl V

更新日期：1982-10-15 00:00:00

abstract：:Conjugates (immunotoxins) comprising ricin A-chain and monoclonal antibody 96.5, which is specific for human melanoma-associated antigen p97, inhibited protein synthesis and colony formation of cultured human melanoma cells that expressed more than 80,000 molecules of p97 per cell. Cells expressing fewer than 5,000 mo...

journal_title：International journal of cancer

authors： Casellas P,Brown JP,Gros O,Gros P,Hellström I,Jansen FK,Poncelet P,Roncucci R,Vidal H,Hellström KE

更新日期：1982-10-15 00:00:00

abstract：:In our previous experiments in Syrian hamsters the in vivo semiquantitative method of determination of the natural resistance-depressing (NRD) activity of tumor cells was described. It was demonstrated that inactivated cells of different tissue culture cell lines derived from in vivo tumors in contrast to normal, or i...

journal_title：International journal of cancer

authors： Deichman GI,Kluchareva TE,Kashkina LM,Matveeva VA,Vendrov EL,Zemtsova VI

更新日期：1982-09-15 00:00:00

abstract：:The following studies were undertaken to determine the levels of serum carotene and vitamin A (retinol) in Egyptian patients with intestinal, urinary, hepatosplenic schistosomiasis, and bladder cancer. These studies have shown that both serum carotene and serum retinol levels are significantly reduced in patients with...

journal_title：International journal of cancer

authors： Mahmoud LA,Robinson WA

更新日期：1982-08-15 00:00:00

abstract：:Human alpha interferon (IFN-alpha) and beta interferon (IFN-beta) showed antiviral and anticellular effects on human lymphoblastoid Daudi and P3HR-1 cells, but up to 1,000 units/ ml of gamma interferon (IFN-gamma) showed no such effect. Though a fairly high level of dsRNA-dependent 2'-5'-oligoadenylate synthetase (2-5...

journal_title：International journal of cancer

authors： Tomita Y,Cantell K,Kuwata T

更新日期：1982-08-15 00:00:00

abstract：:Mouse IFN gamma preparations purified 30-fold were found to have direct cytolytic activity against a number of tumor and normal cells. Cell killing was determined using a sensitive, rapid and accurate assay which employed very low numbers of cells and very small quantities of interferon. The cytolytic activity of IFN ...

journal_title：International journal of cancer

authors： Tyring S,Klimpel GR,Fleischmann WR Jr,Baron S

更新日期：1982-07-15 00:00:00

abstract：:The growth of a spontaneous adenocarcinoma (ADK-1t) of BALB/c mice (H-2d, MIsb) induces progressive hyporesponsiveness of spleen cells stimulated with PHA or irradiated leukocytes from DBA/2 strain (H-2d, MIsa) in mixed leukocyte culture. This hyporesponsiveness is due to the suppressor activity of macrophage-like cel...

journal_title：International journal of cancer

authors： Forni G,Giovarelli M,Lanfrancone L,Varesio L

更新日期：1982-06-15 00:00:00

abstract：:Immunization of mice with 10(6) irradiated LSTRA murine leukemia cells (LX) induced weak immunity to subsequent tumor-cell challenge. Admixture of low doses (1.4-14 micrograms of C. parvum with the LX usually augmented the immunity. Higher doses (1,400-7,000 micrograms) of admixed C. parvum not only failed to augment ...

journal_title：International journal of cancer

authors： Titus MJ,Bartlett GL,Kreider JW

更新日期：1982-06-15 00:00:00

abstract：:Murine mammary aplastic carcinoma, when it is passed from one alloxan-diabetic animal to another, after several passages becomes conditioned to hypoinsulinemia by secreting its own substance(s) immunologically cross-reactive with insulin (SICRI). Although not cytotoxic, the total daily dose of 2.5 mg of synthetic line...

journal_title：International journal of cancer

authors： Vuk-Pavlović S,Bozikov V,Pavelić K

更新日期：1982-06-15 00:00:00

abstract：:Infection of (C57BL/6 X DBA/2)F1 (BDF1) mice with 2,500 FFU of Friend virus complex (FV) resulted in erythroleukemia followed by recovery, at which time virus could not be detected in the spleens of mice, and with splenomegaly (progressor mice) or without splenomegaly (regressor mice). Progressor and regressor mice de...

journal_title：International journal of cancer

authors： Yoosook C

更新日期：1982-06-15 00:00:00